Simulation of magnetic active polymers for versatile microﬂuidic devices
St. Poelten University of Applied Sciences, St. Poelten, Austria
2 AIT Austrian Institute of Technology, Vienna, Austria
a e-mail: email@example.com
We propose to use a compound of magnetic nanoparticles (20–100 nm) embedded in a ﬂexible polymer (Polydimethylsiloxane PDMS) to ﬁlter circulating tumor cells (CTCs). The analysis of CTCs is an emerging tool for cancer biology research and clinical cancer management including the detection, diagnosis and monitoring of cancer. The combination of experiments and simulations lead to a versatile microﬂuidic lab-on-chip device. Simulations are essential to understand the inﬂuence of the embedded nanoparticles in the elastic PDMS when applying a magnetic gradient ﬁeld. It combines ﬁnite element calculations of the polymer, magnetic simulations of the embedded nanoparticles and the ﬂuid dynamic calculations of blood plasma and blood cells. With the use of magnetic active polymers a wide range of tunable microﬂuidic structures can be created. The method can help to increase the yield of needed isolated CTCs.
© Owned by the authors, published by EDP Sciences, 2013