Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
1 Niels Bohr Institute, University of Copenhagen, 2100 Copenhagen, Denmark
2 Instituto de Biociências - Universidade Estadual Paulista – CP. 510, 18618-970 Botucatu – SP, Brazil
3 Institut Laue-Langevin, BP. 156, 38042 Grenoble, France
4 Dipartimento di Fisica, Università di Perugia, 06123 Perugia, Italy
5 Department of Applied Physics, Chalmers University of Technology, 41296 Göteborg, Sweden
6 Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., Tampa, Florida 33620, USA
7 Laboratory for Neutron Scattering, Paul Scherrer Institute, 5232 Villigen, Switzerland
Published online: 23 January 2015
The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.
© Owned by the authors, published by EDP Sciences, 2015
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