Deep tumor imaging by upconversion nanoparticles
N. N. Blokhin Russian Cancer Research Center, Moscow 115478, Russia
2 I. M. Sechenov First Moscow State Medical University, Moscow 119991, Russia
3 Federal Scientific Research Center Crystallography and Photonics RAS, Moscow 119333, Russia
4 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia
5 Institute of Fine Chemical Technologies, Moscow Technol. University, Moscow 119571, Russia
* Corresponding author: email@example.com
Published online: 26 September 2018
In this work are shown the prospects of using upconversion nanoparticles (UCNPs) as markers for contrast optical imaging of a tumor. For using nanoparticles for biomedical purposes is implemented a technique for coating nanoparticles with polymers, such as PEG and PSA. This approach provides low non-specific adsorption, which prolongs the circulation of UCNPs in mouse bearing Lewis Lung Cancer (LLC) up to 10 hours. These properties allow nanoparticles to quickly accumulate in the tumor. Effective delivery of particles with different polymer coatings in the tumor is demonstrated with the help of an epiluminescent imaging system.
© The Authors, published by EDP Sciences, 2018
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