Calibration of Circulating Tumor Cell’s Model in Narrow Flow
University of Žilina, Faculty of Management Science and Informatics, Department of Software Technology, Žilina, Slovakia
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Published online: 28 June 2019
In this article our objective was to calibrate model of Circulating Tumor Cell (CTC). Diﬀerent types of cancer produce diﬀerent types of CTCs. For research purposes, we chose to set up the model according to MCF7 breast cancer cell lines, due to the availability of data from laboratory experiments. First, to obtain working model we used mechanics of our already existing RBC model, taking into consideration the diﬀerences between RBC and CTC. Next step was to find values for the elastic parameters of the cell model. We have chosen laboratory experiment where the deformability of breast cancer cell passing through narrow microfluidic channel was examined. The channel has similar dimensions as blood capillaries to mimic the in vivo environment. In order to achieve similar behavior of the cell’s model and the real cell in the experiment we needed to set fluid flow according to experimental data. This was achieved by adjusting the fluid force that is dependent on the volumetric flow rate. Due to the long computational time of the simulation we devised a function between the entry time and the volumetric flow rate. Afterwards we also found dependencies between the changes in elastic parameters and entry time, and we were able to set the elastic parameters so they mimic the behaviour from the laboratory experiment. Further work lies in validating these results.
© The Authors, published by EDP Sciences, 2019
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