Express Screening of Tear Fluid for Evaluation of the Concentration of Lanomax Using Multisensory Stripping Voltammetry and Multivariate Statistics
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, RU-119071, Moscow, Russia
2 Pirogov Russian National Research Medical University, RU-117997, Moscow, Russia
3 Lomonosov Moscow State University, Skobeltsyn Institute of Nuclear Physics, RU-119991, Moscow, Russia
4 International Research and Practice Center for Tissue Proliferation, Non-commercial Partnership, Russia
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Published online: 9 December 2019
The drug concentrations monitoring is very important for finding the right dosage. The developed method is based on the recognition of multidimensional images, which are produced by multisensory electrochemical systems that provide reliable information on objects being tested, using multidimensional statistics. The measurements were carried out using a planar solid-state electrode. The test solution was a 0.05 M KCl solution, which contained the and metal cations in the concentration of 5 • 10−5 M. The efficiency of this method in determining lanosterol with accounting for changes in its concentration with over time has been demonstrated. In order to determine concentrations of Lanomax in tear fluid, a procedure for multisensory stripping voltammetry has been developed and tested. It has been shown that the effect of lacrimal fluid on metal dissolution currents in the test system lasts 12 hours after the Lanomax instillation.
© The Authors, published by EDP Sciences, 2019
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