MAPSSIC, a communicating MAPS-based intracerebral positrons probe for deep brain imaging in awake and freely-moving rats
Aix Marseille Univ, CNRS/IN2P3, CPPM,
M. Bautista, F. Gensolen, P. Pangaud, and C. Morel are with the Aix Marseille Univ, CNRS/IN2P3, CPPM, Marseille, France.
L. Ammour, F. Lefebvre, L. Pinot, P. Laniece and M-A Verdier are with the Imagerie et Modélisation en Neurobiologie et Cancérologie (IMNC), CNRS, Univ Paris Sud, Université Paris-Saclay, F-91406 Orsay, France.
L. Ammour, F. Lefebvre, L. Pinot, P. Laniece and M-A Verdier are with Université de Paris, IMNC, F-91400 Orsay, France
J. Heymes, M. Kachel, and J. Baudot are with the Université de Strasbourg, CNRS, IPHC UMR 7178, Strasbourg, France.
S. Fieux and L. Zimmer are with the CERMEP-Imagerie du vivant, Université Claude Bernard Lyon 1, CNRS, INSERM, Hospices Civils de Lyon, Lyon, France.
P. Gisquet-Verrier is with the NeuroPSI CNRS/INSB, Univ Paris Sud, Orsay, France.
Published online: 20 January 2020
Radioisotope imaging is a powerful tool to understand the biological mechanisms in-vivo, especially in the brain of small animals, providing a significant model to study the human brain.
In this context, we have developed and built a pixelated intracerebral positron probe to be embedded on awake and freely moving small animals, typically rats. This pixelated probe will represent a key instrument for neuroscientists to study neural mechanisms and correlate them to behavioral experiments.
We describe in this paper the simulations carried out to design the intracerebral sensor, its architecture, and the detection of positrons in a volume with a couple of sensors assembled back-to-back. We also depict the architecture of the wireless acquisition system. Finally, we present the first measurements performed in real-time by this miniaturized probe with sealed radioactive sources and a 18F solution.
Key words: Active pixel sensors / Animal behavior / CMOS Image sensors / Implants / Molecular imaging / Monte Carlo methods / Nuclear Imaging / Positron emission tomography
© The Authors, published by EDP Sciences, 2020
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