In-vitro measurement of aerosol generated by Respimat SMI penetrating through upper airways
1 Faculty of Mechanical Engineering, Brno University of Technology, Technická 2896/2, 616 69 Brno
2 Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackého 1946/1, 612 42 Brno
* Corresponding author: Ondrej.Misik@vutbr.cz
Published online: 24 October 2022
Respimat soft mist inhaler (SMI) is an inhaler producing a soft mist with low velocity. The liquid drug solution is emitted by the mechanical energy of compressed spring, so the device is propellant-free. This paper describes the measurement of particle fraction penetrating through the model of the upper respiratory tract (mouth cavity, pharynx, larynx trachea). The solution inside the cartridge was marked by fluorescein in order to evaluate the regional particle deposition in the model. After the exposition, segments of the model, as well as the filter, were washed out and the deposited fluorescein was extracted into water. The analysis showed that the fraction of particles penetrating through the upper respiratory tract was 64.7±6.7 %. However, the real inhalation pattern was not simulated and measurement was provided with continual “inhalation” without “exhalation”.
© The Authors, published by EDP Sciences, 2022
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