https://doi.org/10.1051/epjconf/202328704010
Remote plasmonic-enhanced Raman spectroscopy with the plasmon-molecule coupling in distance over 100 nm
1 Institute of Post-LED Photonics, Tokushima University, Tokushima 770-8506, Japan
2 Technology & Engineering Division, Ushio Inc., Hyogo 671-0224, Japan.
3 The Institute of Science and Industrial Research, Osaka University, Osaka 567-0047, Japan.
4 Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
* Corresponding author: minamikawa.takeo@tokushima-u.ac.jp
Published online: 18 October 2023
We propose remote plasmonic-enhanced Raman scattering (RPERS) spectroscopy for molecular sensing and imaging applications. RPERS requires no contact between analyte molecules and metallic nanostructures, which overcomes the limitations of surface-enhanced Raman scattering (SERS). We constructed RPERS substrates consisting of silver nanoislands and columnar silica structures, which demonstrated a 2×107 enhancement in Raman scattering for Rhodamine 6G molecules, even when the metal nanostructures and analyte molecules were over 100 nm apart. The RPERS substrate also exhibited improved reproducibility (<15% RSD), long-term stability (>1 month), and sensitivity (>10 times) compared to conventional SERS substrates. We also confirmed the feasibility of RPERS for biophotonic analysis, i.e., enhancing Raman histological imaging of oesophagus tissues with oesophageal adventitia of a Wistar rat attached atop the columnar silica structure layer. Our demonstration is a promising advancement in the field of enhanced spectroscopy using plasmon and offers a solution to the challenges faced by conventional SERS spectroscopy. It has the potential to pave the way for future developments in remote plasmonic-enhanced spectroscopy.
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
