https://doi.org/10.1051/epjconf/202430904024
Terahertz Radiation for Demethylation of Cancer Cells
1 University of Seoul, Seoul 02504, Republic of Korea
2 iNexus, Inc., Gyeonggi-do 13486, Republic of Korea
* Corresponding author: joohiuk@uos.ac.kr
Published online: 31 October 2024
Carcinogenesis involves DNA methylation which is a primary alteration in DNA in the development of cancer before genetic mutation. Because the abnormal DNA methylation is found in most cancer cells, the assessment of DNA methylation using terahertz radiation can be a novel optical method to detect and control cancer. The methylation has been directly observed by terahertz time-domain spectroscopy and this epigenetic chemical change could be manipulated to the state of demethylation using resonant terahertz radiation. Demethylation of cancer cells is a key issue in epigenetic cancer therapy and our results demonstrate the feasibility of the cancer treatment using optical technique.
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
