https://doi.org/10.1051/epjconf/202430910014
Femtosecond laser ablation of 3D-printed PCL Scaffolds as a strategy to enhance bone tissue regeneration efficacy
1 Photonics4Life Research Group, Applied Physics Department, Facultade de Física and Facultade de Óptica e Optometría, Universidade de Santiago de Compostela, Campus Vida, E15782 Santiago de Compostela, Spain
2 Department of Pharmacology, Pharmacy, and Pharmaceutical Technology, I+D Farma (GI-1645), Facultade de Farmacia, and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, E15782 Santiago de Compostela, Spain
3 Instituto de Materiales (iMATUS), Universidade de Santiago de Compostela, E15782 Santiago de Compostela, Spain
* Corresponding author: maite.flores@usc.es
Published online: 31 October 2024
New photonic techniques need to be developed to improve personalised medicine methods in tissue engineering. In the case of severe bone injuries, difficulties arise when creating platforms where cells required to be efficiently adhered. Femtosecond laser ablation appears as a versatile technique for modifying the surface of materials with high precision and neat outcomes. Thus, a strategy combining 3D printing of biopolymeric scaffolds and femtosecond laser ablation is proposed to design a device with enhanced material properties in terms of cell growth for bone tissue regeneration. Three different patterns were proposed, and it was proven that cell adhesion improvements rely on the pattern profile, assessing that grooved scaffold successfully increased cell adhesion and proliferation in comparison with micropitted samples.
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
