A novel avalanche-confinement TEPC for microdosimetry at nanometric level
1 Politecnico di Milano, Dipartimento di Energia, via La Masa 34, Milano, Italy
2 Istituto Nazionale di Fisica Nucleare - INFN, Sezione di Milano, via Celoria 16, Milano, Italy
3 Laboratori Nazionali di Legnaro LNL-INFN, viale dell’Università 2, Legnaro (Padova), Italy
* Corresponding Author: firstname.lastname@example.org
Published online: 25 September 2017
The tissue equivalent proportional counter (TEPC) is the most accurate device for measuring the microdosimetric properties of a particle beam, showing to properly assess the relative biological effectiveness by linking the physical parameters of the radiation with the corresponding biological response. Nevertheless no detailed information on the track structure of the impinging particles can be obtained, since the lower operation limit of the common TEPCs is about 0.3 ?m. On the other hand, the pattern of particle interactions at the nanometer level, which demonstrated to have a strong correlation with radiation-induced damages to the DNA, is directly measured by only three different nanodosimeters worldwide: practical instruments are not yet available.
The gap between microdosimetry and track-nanodosimetry can be filled partially by extending the TEPC response down to the nanometric region. A feasibility study of a novel TEPC designed to simulate biological sites in the nanometric domain was performed. The present paper aims at describing the design, the development and the characterization of this avalanche-confinement TEPC. Irradiations with photons, fast neutrons and low-energy carbon ions demonstrated the capability of this TEPC of measuring in the range 0.3 μm - 25 nm.
© The Authors, published by EDP Sciences, 2017
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