https://doi.org/10.1051/epjconf/201920404007
Modeling the influence of heavy ion beams on neurogenesis and functioning of hippocampal neural networks
Joint Institute for Nuclear Research, Dubna, Russia
* e-mail: ea.malakhova@gmail.com
Published online: 3 April 2019
Radiation-induced impairment of hippocampal neurogenesis is one of serious factors associated with cognitive detriments after radiation therapy of brain cancers and realization of long-term manned space flights. The goal of this study is to develop a mathematical model describing radiation-induced changes in cellular populations participating in neurogenesis and how these alterations worsen the processing of information by hippocampus. Modeling results have demonstrated that heavy ions may cause non-reversible suppression of neurogenesis, which is followed by failure of pattern encoding and retrieval by hippocampal neural networks.
© The Authors, published by EDP Sciences, 2019
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
