https://doi.org/10.1051/epjconf/202328703010
Terahertz ATR sheds light on real-time exchange kinetics occurring through plasma membrane during photodynamic therapy
1 Laboratory for Optics and Biosciences, Ecole polytechnique, CNRS, INSERM, IP Paris, Palaiseau, France
2 Laboratoire des IMRCP, Université de Toulouse, CNRS UMR 5623, 31062 Toulouse, France
3 Centre de Microscopie Electronique Appliquée à la Biologie, Université de Toulouse, 31062 Toulouse, France
* Corresponding author: Guilhem.Gallot@polytechnique.edu
Published online: 18 October 2023
THz ATR spectroscopy provides, in a single measurement, the relative number of defects per membrane surface created by oxidative stress generated during photodynamic therapy (PDT), offering early, sensitive real-time information. THz spectroscopy is therefore a complementary technique to established (biological) assays and can be applied to any topic requiring the real-time examination of short-term plasma membrane permeabilization.
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
