Proceedings

EPJ E Highlight - How ion adsorption affects biological membranes’ functions

Coverage of the lipid bilayer membrane surface with ions, as a function of pH.

A new study presents new models describing how the adsorption of calcium, barium and strontium ions onto biological membranes may affect the functions of cells

Ions with two positive electrical charges, such as calcium ions, play a key role in biological cell membranes. The adsorption of ions in solution onto the membrane surface is so significant that it affects the structural and functional properties of the biological cells. Specifically, ions interact with surface molecules such as a double layer of lipids, or liposomes, formed from phosphatidylcholines (PC). In a new study published in EPJ E, Izabela Dobrzyńska from the University of Białystok, Poland, develops a mathematical model describing the electrical properties of biological membranes when ions such as calcium, barium and strontium adsorb onto them at different pH levels. Her works helps shed light on how ion adsorption reduces the effective surface concentration of add-on molecules with a specific function that can take part in biochemical reactions. These factors need to be taken into account when studying the diverse phenomena that occur at the lipid membrane in living cells, such as ion transport mechanisms.

The equilibrium at the membrane surface can be changed by the ion adsorption levels, leading to variations in the membrane surface charge density. Using a method called microelectrophoresis, the author experimentally determines the surface charge density as a function of pH. She then develops a mathematical model of the surface charge density to identify the equilibrium, and finds that her model agrees with experimental data.

Dobrzyńska finds that calcium ions have a greater ability to adsorb onto the lipid bilayer of the biological membrane than barium ions. In addition, she observes that ions containing hydroxide endings are adsorbed onto the membrane more readily than positively charged metal ions, like strontium. Ions’ adsorption onto the surface of the liposomes may affect their movement through the cell membrane, and with it, the delivery of the substances they carry.

In the last years, I contributed to organize different scientific events with the University of Messina and the Bonino-Puleio foundation and with the support of the INFN. In the most of cases, we decided to publish the proceedings in the EPJ Web of Conferences. The main reasons of this choice are: the cost of the publication is very competitive with respect the other publisher (important to justify the expense with the own administration), the quality of the services are excellent from different points of view: the publishing editor and Collaborators are kind to furnish very soon all information and to process all requests, they are able to publish the proceedings in very short time and with high quality. The journal provides also citation indexing via ISI Web of Knowledge and Scopus, very important for the visibility of the articles and the authors.

Giuseppe Mandaglio, University of Messina, Italy
Co-editor EPJ Web of Conferences vol. 142 (2017)

ISSN: 2100-014X (Electronic Edition)

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