EPJ E Colloquium – The importance of rheology in tissue development

Our understanding of biomechanics increasingly improves through the use of physics models. There are some intriguing biological questions regarding the interplay between the behaviour of cells and the mechanics at the level of tissues. For example, how does a collective behavior, not apparent at the cell scale, emerge at the tissue level? Or how can the mechanical state of a tissue affect the cell division rate or the orientation of cells undergoing division?

The authors of this new EPJ E Colloquium entitled “Mechanical Formalism for Tissue Dynamics” think that the interplay between genes and mechanics is key to understanding how the adult shape emerges from a developing tissue.

In this Colloquium the authors construct rheological diagrams based on insights concerning the mechanics of the biological tissue. One of the main insights is a distinction between intra-cellular and inter-cellular mechanism. The local rheological equations that they obtain allow them to generate a complete spatial model expressed as a set of partial differential equations. This procedure is conducted not only in the usually treated case of small elastic deformations, but also in the relevant, less discussed, case of large elastic deformations. With this paper the authors provide a functional and versatile toolbox for tissue modelling and propose a framework for a tensorial treatment of heterogeneous tissues. Although the simplest applications concern in vitro experiments, the same approach may be used for many other living tissues including animal tissues during development, wound healing, or carcinogenesis.

This was our first experience of publishing with EPJ Web of Conferences. We contacted the publisher in the middle of September, just one month prior to the Conference, but everything went through smoothly. We have had published MNPS Proceedings with different publishers in the past, and would like to tell that the EPJ Web of Conferences team was probably the best, very quick, helpful and interactive. Typically, we were getting responses from EPJ Web of Conferences team within less than an hour and have had help at every production stage.
We are very thankful to Solange Guenot, Web of Conferences Publishing Editor, and Isabelle Houlbert, Web of Conferences Production Editor, for their support. These ladies are top-level professionals, who made a great contribution to the success of this issue. We are fully satisfied with the publication of the Conference Proceedings and are looking forward to further cooperation. The publication was very fast, easy and of high quality. My colleagues and I strongly recommend EPJ Web of Conferences to anyone, who is interested in quick high-quality publication of conference proceedings.

On behalf of the Organizing and Program Committees and Editorial Team of MNPS-2019, Dr. Alexey B. Nadykto, Moscow State Technological University “STANKIN”, Moscow, Russia. EPJ Web of Conferences vol. 224 (2019)

ISSN: 2100-014X (Electronic Edition)

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