https://doi.org/10.1051/epjconf/202328703013
Diffuser-based fiber endoscopy for single-shot 3D fluorescence imaging
1 Laboratory of Measurement and Sensor System Technique, TU Dresden
2 Competence Center for Biomedical Computational Laser Systems (BIOLAS), TU Dresden
3 Else Kröner Fresenius Center for Digital Health (EKFZ), TU Dresden
4 Cluster of Excellence Physics of Life, TU Dresden
* e-mail: tom.glosemeyer@tu-dresden.de
Published online: 18 October 2023
Minimally invasive endoscopy using coherent fiber bundles shows great potential for numerous applications in biomedical imaging. With a diffuser on the distal side of the fiber bundle and computational image recovery, single-shot 3D imaging is possible by encoding the image volume into 2D speckle patterns. In comparison to equivalent lens systems, a higher space-bandwidth product can be achieved. However, decoding the image with iterative algorithms is time-consuming. Thus, we propose utilizing a neural network for fast 2D and 3D image reconstruction at video rate. In this work, single-shot 3D fluorescence imaging with an ultra-thin endoscope is demonstrated, enabling applications like calcium imaging for in vivo brain diagnostics at cellular resolution.
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
