EPJ D Highlight - Breaking up amino acids with radiation

Mass spectra of the fragments obtained from glutamine molecules at different radiation doses.

A new study describes how the amino acid, glutamine, is broken up when bombarded with different doses of electrons. This has implications for cancer radiotherapy and understanding the origin of life.

Small organic molecules, including the amino acids that form the ‘building blocks’ of proteins in living cells, fragment to form ions under the impact of high-energy radiation such as electron beams. A new study published in EPJ D has now shown what happens when electrons collide with one amino acid, glutamine. The extent of the damage and the nature of the ions formed are both affected by the energy of the colliding electrons. This work arises from a collaboration between experimental physicists led by Alexander Snegursky at the Institute of Electron Physics, Uzhgorod, Ukraine and theoreticians led by Jelena Tamuliene at Vilnius University, Vilnius, Lithuania.

The damaging effect of very high-energy radiation on human tissue is well-known from disasters such as the nuclear accidents at Chernobyl and Fukushima. However, the long-term effects experienced by survivors of such disasters, including an increased risk of cancer, are partly caused by the impact of rather lower-energy radiation. The groups chose to study the effect of electron impact on amino acids because they are less widely studied in this context than DNA.

Snegursky and his colleagues used mass spectrometry to measure the mass-to-charge ratio and thus determine the nature of chemical fragments produced when one biologically important amino acid, glutamine, was bombarded with uniform electron beams with different radiation doses. Meanwhile, the theoretical team modelled the electronic and geometric structures of glutamine and its fragments using quantum mechanics. The observed fragmentation patterns differed according to the radiation dose that the molecules received, and the experimental results were largely borne out by the simulations. The study authors believe that this basic research will have implications for understanding the effect of ionising radiation on human cells, improving the selectivity of radiotherapy beams for cancer cells, and even, perhaps, understanding the origin of life.

This was our first experience of publishing with EPJ Web of Conferences. We contacted the publisher in the middle of September, just one month prior to the Conference, but everything went through smoothly. We have had published MNPS Proceedings with different publishers in the past, and would like to tell that the EPJ Web of Conferences team was probably the best, very quick, helpful and interactive. Typically, we were getting responses from EPJ Web of Conferences team within less than an hour and have had help at every production stage.
We are very thankful to Solange Guenot, Web of Conferences Publishing Editor, and Isabelle Houlbert, Web of Conferences Production Editor, for their support. These ladies are top-level professionals, who made a great contribution to the success of this issue. We are fully satisfied with the publication of the Conference Proceedings and are looking forward to further cooperation. The publication was very fast, easy and of high quality. My colleagues and I strongly recommend EPJ Web of Conferences to anyone, who is interested in quick high-quality publication of conference proceedings.

On behalf of the Organizing and Program Committees and Editorial Team of MNPS-2019, Dr. Alexey B. Nadykto, Moscow State Technological University “STANKIN”, Moscow, Russia. EPJ Web of Conferences vol. 224 (2019)

ISSN: 2100-014X (Electronic Edition)

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