EPJ D Colloquium - Multiscale approach to the physics of radiation damage with ions

Features, processes, and disciplines, associated with radiation therapy shown in a space–time diagram, which shows approximate temporal and spatial scales of the phenomena. The history from ionization/exciation to biological effects on the cellular level are shown in the main figure and features of ion propagation are shown in the inset.

In this EPJ D Colloquium, the authors review the multiscale approach to the assessment of biodamage that results from the irradiation of biological media with ions. This approach is explained in depth and compared to other approaches. The ion propagation processes that take place in the medium concurrent with ionisation and excitation of molecules, transport of secondary products, dynamics of the medium, and biological damage, take place on a number of different temporal, spatial and energy scales. The multiscale approach, a physical phenomenon-based analysis of the scenario that leads to radiation damage, has been designed to consider all relevant effects on a variety of scales and to enable quantitative assessment of biological damage as a result of irradiation with ions.

In this work, physical and chemical effects are included in the scenario while the biological effects, such as DNA repair, are also briefly discussed. The phenomenon of radiation damage due to ions is explained, an overview of its major components is presented, and the multiscale approach is applied to investigate different experimental conditions.

On the basis of this experience, a step-wise guide for the application of the multiscale approach is formulated. The guide culminates in the calculation of relative biological effectiveness.

This was our first experience of publishing with EPJ Web of Conferences. We contacted the publisher in the middle of September, just one month prior to the Conference, but everything went through smoothly. We have had published MNPS Proceedings with different publishers in the past, and would like to tell that the EPJ Web of Conferences team was probably the best, very quick, helpful and interactive. Typically, we were getting responses from EPJ Web of Conferences team within less than an hour and have had help at every production stage.
We are very thankful to Solange Guenot, Web of Conferences Publishing Editor, and Isabelle Houlbert, Web of Conferences Production Editor, for their support. These ladies are top-level professionals, who made a great contribution to the success of this issue. We are fully satisfied with the publication of the Conference Proceedings and are looking forward to further cooperation. The publication was very fast, easy and of high quality. My colleagues and I strongly recommend EPJ Web of Conferences to anyone, who is interested in quick high-quality publication of conference proceedings.

On behalf of the Organizing and Program Committees and Editorial Team of MNPS-2019, Dr. Alexey B. Nadykto, Moscow State Technological University “STANKIN”, Moscow, Russia. EPJ Web of Conferences vol. 224 (2019)

ISSN: 2100-014X (Electronic Edition)

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